English הצהרה מפת האתר ארועים צור קשר דף הבית  
דף הבית מכוני מחקר ותשתיות המכון הלאומי לאוקיאנוגרפיה חוקרי המכון ברוריה פונקנשטין

National Institute of Oceanography

Bruria Funkenstein

bruria@ocean.org.il
Tel: 04 – 8565263

Senior Scientist

Ph.D. 1981, Weizmann Institute of Science, Israel
At IOLR since 1986

Research interests:
Studies related to growth regulation of marine fish at the molecular level, including ontogeny of growth-related genes and use of biotechnological approaches to improve fish growth. Application of molecular and biochemical markers for endocrine disruption in the marine environment.

Selected publications:
Almuly, R., Cavari, B., Ferstman, H., Kolodny, O. and Funkenstein, B. (2000). Genomic structure and sequence of the gilthead sea bream (Sparus aurata) growth hormone-encoding gene: identification of minisatellite polymorphism in intron I. Genome 43:836-845.

Almuly, R., Poleg-Danin, Y., Gorshkov, S., Gorshkova, G., Rapoport, B., Soller, M., Kashi, Y. and Funkenstein, B. (2005). Characterization of the 5 prime flanking region of the growth hormone gene of the marine teleost, gilthead sea bream Sparus aurata: analysis of a polymorphic microsatellite in the proximal promoter. Fish. Sci. 71:479-490.

Funkenstein, B., Balas, V., Skopal, T., Radaelli, G. and Rowlerson, A. (2006). Long-term culture of muscle explants from Sparus aurata. Tissue Cell 38:399-415.

Funkenstein, B. and Rebhan, Y. (2007). Expression, purification, renaturation and activation of fish myostatin expressed in Escherichia coli: facilitation of refolding and activity inhibition by myostatin prodomain. Protein. Expr. Purif. 54:54-65.

Almuly, R., Skopal, T. and Funkenstein, B. (2008). Regulatory regions in the promoter and first intron of Sparus aurata growth hormone gene: repression of gene activity by a polymorphic minisatellite. Comp. Biochem. Physiol.(D). 3:43-50.

Rebhan, Y. and Funkenstein, B. (2008). Inhibition of fish myostatin activity by recombinant fish follistatin and myostatin prodomain: potential implications for enhancement of muscle growth in farmed fish. Aquaculture 284: 231-238.

Funkenstein, B., V. Balas, Y. Rebhan, and A. Pliatner (2009). Characterization and functional analysis of the 5’ flanking region of Sparus aurata myostatin-1 gene. Comp. Biochem. Physiol. Part A. Mol. Integ. Physiol. 153A: 55-62.

Funkenstein, B. and Olekh, E. (2010). Growth/differentiation factor-11: an evolutionary conserved growth factor in vertebrates. Dev. Genes Evol. 220: 129-137.

Funkenstein, B., Krol, E., Estrin, E. and Kim, Y.S. (2012). Structural and functional characterizations of activin type IIB receptor (ActRIIB) ortholog from the marine fish gilthead sea bream Sparus aurata: evidence for gene duplication of ActRIIB in fish. J. Mol. Endocrinol. 49: 175-192.

Nadjar-Boger, E. and Funkenstein, B. (2011). Myostatin-2 gene structure and polymorphism of the promoter and first intron in the marine fish Sparus aurata: evidence for DNA duplications and/or translocations. BMC Genetics 12: 22.

Nadjar-Boger, E., Hinits, Y. and Funkenstein, B. (2012). Structural and functional analysis of myostatin-2 promoter alleles from the marine fish Sparus aurata: evidence for strong muscle-specific promoter activity and post-transcriptional regulation. Mol. Cell. Endocrinol. 361: 51–68.

Funkenstein, B., Dyman, A., Levavi-Sivan, B. and Tom, M. (2004). Application of real-time PCR for quantitative determination of hepatic vitellogenin transcript levels in the striped sea bream, Lithognathus mormyrus. Mar. Environ. Res. 58:659-663.

Funkenstein, B., Bowman, C.J., Denslow, N.D., Cardinali, M. and Carnevali, O. (2000). Contrasting effects of estrogen on transthyretin and vitellogenin expression in males of the marine fish, Sparus aurata. Mol. Cell. Endocrinol. 167:33-41.
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